We have created double-stranded oligonucleotide arrays to perform highly parallel investigations of DNA–protein interactions. Arrays of single-stranded DNA oligonucleotides, synthesized by a ...

Trevor A. Graham is at the Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK. Sarah E. McClelland is at the Centre for ...

Antisense oligonucleotides (ASOs) are small, single-stranded molecules that can suppress the expression of targeted genes and thereby achieve therapeutic effects. However, many ASO-based drug ...

Next-generation sequencing (NGS) has made analyzing DNA faster and cheaper, with effects felt in the lab, clinic, and beyond. A set of newly-launched technologies are offering a twist on the chemistry ...

Researchers in China have developed a new method that allows them to insert long stretches of DNA into a genome. The process, named GRAND editing, is one of a handful of new systems aimed at using two ...