In single-arm trials, false-positive error rates (type I error) were 2 to 4 times those projected when modest drift or patient selection effects (eg, 5% absolute ...

Randomised clinical trials (RCTs) remain the gold standard in evaluating therapeutic interventions, ensuring that treatment effects are not confounded by systematic errors. Central to these trials is ...

This transcript has been edited for clarity. Eric J. Topol, MD: Hello. This is Eric Topol with my co-host Abraham Verghese for Medscape Medicine and the Machine. We have Professor Trisha Greenhalgh ...

A review of studies published in JAMA Network Open found few randomized clinical trials for medical machine learning algorithms, and researchers noted quality issues in many published trials they ...

In order to provide gender-affirming care, clinicians must sometimes jump through unusual hoops. In Australia, for example, the government won’t subsidize testosterone treatment for a trans man ...