Increasing the surface area of the joint enhances its strength. You can do this by adding biscuits, dominoes or splines inside of the joint itself, or by cutting your material to enhance the glue ...

You can do a lot with acrylic and few tools. If you’re just starting out we’d suggest taking a look at [Michael Colombo’s] guide to heating, bending, and gluing to create custom acrylic enclosures.