When researchers verify the effects of genes or gene–environment interactions on common diseases or age-related diseases, such as diabetes, cancer, or coronary heart disease, they usually regard age ...

In the case of frequency data, traditional discussions such as Rao (1973, pages 355-363, 391-412) consider asymptotic properties of maximum likelihood estimates and chi-square statistics under the ...

A hybrid method that combines Laplace's approximation and Monte Carlo simulations to evaluate integrals in the likelihood function is proposed for estimation of the parameters in nonlinear mixed ...

In a recent study posted to the medRxiv* preprint server, an interdisciplinary team of researchers from the United States (US) assessed predictions of the laboratory-confirmed coronavirus disease 2019 ...