·负担沉重：启动接触者追踪、定义暴露范围、进行大规模检测，不仅耗费巨资（美国每年估计花费990万美元），还给医护人员（HCP）和患者带来极大的心理压力。 ·混杂因素：大多数研究未调整患者病情（如空洞、痰菌载量）及环境因素（如房间大小、换气次数）的影响。

Mycobacterium tuberculosis, the pathogen responsible for tuberculosis, has evolved a remarkably layered set of molecular ...

As of early 2025, tuberculosis cases are increasing in the U.S. This disease, often shortened to TB, causes significant lung damage and, if not treated, is almost always lethal. World TB Day on March ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Disseminated tuberculosis is a type of tuberculosis (TB) where mycobacteria spread via blood to other organs beyond the lungs. It can cause severe multiple-organ damage in the absence of early ...

Tuberculosis is a serious health threat, and the efficacy of the BCG vaccine against tuberculosis diminishes in adulthood, making booster vaccines a realistic option. Mycobacterial DNA-binding protein ...

Branches are colored according to the M. tuberculosis complex lineage: pink for lineage 1, blue for lineage 2, purple for lineage 3, and red for lineage 4. Discrete heat maps next to the phylogeny ...

Untreated tuberculosis may result in several long-term complications, such as permanent lung damage. It’s vital for the condition to be treated early to prevent the infection from traveling to other ...

Tuberculosis (TB) primarily affects the lungs. However, TB-causing bacteria can lead to pus collecting in the tissues. This is known as an abscess. Mycobacterium tuberculosis (M. tuberculosis) is the ...

Tuberculosis (TB) is the world's biggest infectious disease killer with multidrug-resistant TB (MDR-TB) posing a particular threat to global health. A study shows that resistance to the new MDR-TB ...