引言目前，免疫检查点抑制剂（Immune checkpoint inhibitors，ICIs）已广泛用于非小细胞肺癌、小细胞肺癌、乳腺癌、食管癌、肝癌、胃癌、结直肠癌、黑色素瘤等，其主要机制是通过阻断程序性死亡受体-1（Programmed cell death protein 1，PD-1）/程序性死亡受体-配体 1（Programmed cell death protein ligand 1 ...

Cells have the remarkable ability to initiate their own death through a mechanism called programmed cell death, also known as apoptosis. Apoptosis contains sophisticated signalling pathways and ...

A team of researchers at the University of Cologne’s Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that ...

Cancer-killing T cells have been programmed to have two levels of specificity. First, the T cells have been equipped with a receptor sensitive to a protein that is found only in central nervous system ...

This review highlights the critical role of ubiquitin-specific proteases (USPs) in regulating programmed cell death (PCD) in breast cancer (BC). As the most prevalent malignant tumor among women, BC ...

This finding, he suggests, helps link the study of cell death in the worm and oncogenesis in people. "There were a number of papers that had suggested a relationship between cell death and oncogenesis ...

This paper explores the potential of mitochondrial-associated programmed-cell-death (mtPCD) patterns as biomarkers for predicting the prognosis of non-small-cell lung cancer (NSCLC). NSCLC is the most ...

Selective ASO-based JAK2 inhibitor for the treatment of hematological malignancies with JAK2 V617F mutation burden. Use of causal modeling to uncover cell-cell communication dynamics in the tumor ...

A lack of vitamin B2 makes tumour cells more susceptible to a unique form of cell death. This was discovered by researchers at the Rudolf Virchow Centre at the University of Würzburg.

The latest findings on the interaction between cell death and cellular senescence in cancer and their pathophysiological significance have been reviewed. Aging cells secrete substances known to ...