The importance of angiogenesis for growth and viability of solid tumors has been established. Knowledge on these relations in hematological tumors, however, is circumstantial. Tumor microvessel ...

针对COVID-19重症预测缺乏特异性标志物的问题，研究人员聚焦肥大细胞（MC）激活特征，通过检测血清中类胰蛋白酶（tryptase）、羧肽酶A3（CPA3）、糜蛋白酶（chymase）和前列腺素D2（PGD2）水平，构建了多指标联合预测模型。研究发现MC激活与疾病严重程度显著相关 ...

HαT的高患病率及其与血清tryptase水平、严重过敏反应及骨髓检查结果的相关性，影响cMCADs的诊断策略和临床管理，但致病机制及基因检测在治疗中的应用仍需研究。 自十年前首次被描述以来，越来越多的研究揭示了遗传性α-tryptasemia（HαT）在克隆性肥大细胞激活 ...

Tumor angiogenesis is uncontrolled and unlimited in time. It is essential for a tumor's growth, invasion and metastasis during the transition from the avascular to the vascular phase. 1 This paper ...

This is a preview. Log in through your library . Abstract Patients with inflammatory bowel disease (IBD) have increased numbers of human tryptase-β (hTryptase-β)-positive mast cells (MCs) in the ...

HAMPTON, N.J., June 06, 2020 (GLOBE NEWSWIRE) -- Celldex Therapeutics, Inc. (CLDX) today announced results from the Company’s Phase 1 randomized, double-blind, placebo-controlled, dose escalation ...

MultiChip: A new diagnostic tool to perform gene expression analysis and CNV in one array. Background: Tryptase, a serine protease stored and released from mast cells (MCs) granules has been ...

Please provide your email address to receive an email when new articles are posted on . Patients with alpha tryptase had more anaphylaxis than patients who only had B-tryptase. 65% of patients with ...

Adequacy of biopsy samples for molecular testing in patients with non-small cell lung cancer. Analyses of the immunologically relevant gene transcript by qRT-PCR in primary cutaneous melanoma by the ...

In a decade-long study, a ratio of serum acute tryptase to serum baseline tryptase above 1.74 showed superior diagnostic performance compared with the current consensus formula, which requires serum ...

A genetic explanation for a syndrome characterized by multiple frustrating and difficult-to-treat symptoms, including dizziness and lightheadedness, skin flushing and itching, gastrointestinal ...

Please provide your email address to receive an email when new articles are posted on . Tryptase levels were successfully used to identify individuals with severe or milk-induced anaphylaxis, ...