The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

The NFC West may become clearer when the San Francisco 49ers go for a season sweep at home against L.A. Rams. Take Baltimore benind Jackson, the Chargers behind Herbert.

When the San Francisco 49ers square off with the Los Angeles Rams, it will be Sean McVay and Kyle Shanahan, Puka Nacua and Christian McCaffrey, Davante Adams and George Kittle, but all eyes should be on the trenches, because the Los Angeles Rams' star pass rusher against the San Francisco 49ers' star left tackle will decide the game

SANTA CLARA, Calif. — Quarterback Brock Purdy will miss his sixth straight start for the San Francisco 49ers with a toe injury, but could be available in a backup role on Sunday against the Los Angeles Rams.

A young defense with lots of rookies or first-time starters lost stars Nick Bosa and Fred Warner for the entire season in Week 3 and Week 6, respectively. All-Pro tight end George Kittle and wideout Ricky Pearsall have both missed significant time with injuries, as well.

The San Francisco 49ers have been underdogs three times already this year and have lost twice. Their only win was over the Los Angeles Rams, who they are underd

Los Angeles Rams kicker Harrison Mevis is set to make his NFL debut during Sunday's Week 10 matchup at the San Francisco 49ers, head coach Sean McVay told reporters Friday.