This week, the Los Angeles Rams will be looking for revenge against their NFC West foes as they take on the San Francisco 49ers in Santa Clara. Sunday will be t

Can the 49ers' defense overcome injuries and a surging Rams offense? Keys to securing another victory and sweeping their division rival.

The San Francisco 49ers are preparing for their Week 10 contest against the Los Angeles Rams on Sunday at Levi's Stadium in Santa Clara, California. The

NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Los Angeles Rams and San Francisco 49ers.

Rams head coach Sean McVay explains the team's decision to sign long snapper Jake McQuaide and kicker Harrison Mevis to the practice squad and what that means for special teams prep for Week 10 against the 49ers.

If the Los Angeles Rams lose to the San Francisco 49ers in Week 10, it won’t matter if they have almost the same record and eight games left on the schedule. If the Rams lose, their 0-2 division and 1-3 conference records will look like chump change next to 4-0 and 7-1 on San Francisco’s end.

Williams isn’t the only 49er destined for the Hall of Fame who could have ended up in Los Angeles. In 2022, San Francisco general manager John Lynch detailed how he won a “a 49ers-Rams tug-of-war” in getting star running back Christian McCaffrey from Carolina.

The 49ers have a huge divisional showdown Sunday against the Rams, but they may not have Ricky Pearsall or Brandon Aiyuk back for the Week 10 game at Levi's Stadium.