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焦仁杰实验室发现Shaggy/Gsk3β通过调节Hippo信号通路决定器官尺寸大小
Hippo信号通路是最早在果蝇中鉴定出的一条肿瘤抑制通路,在果蝇到人类的多个物种中发挥保守的调节功能,与器官尺寸决定、组织稳态维持、干细胞干性和肿瘤发生紧密相关。研究表明,Hippo通路应答细胞极性、细胞因子和营养状态等输入信号,通过Hippo/MST1/2 ...
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