Introduction Chronic kidney disease (CKD) affects 1 in 10 people worldwide and can progress towards kidney failure, which is ...

Introduction Although there are some drugs to control Parkinson’s disease (PD), they have several side effects and cannot ...

Objectives Metabolic-associated fatty liver disease (MAFLD) is becoming increasingly prevalent worldwide, however, early ...

It is common to undertake qualitative research alongside randomised controlled trials (RCTs) when evaluating complex interventions. Researchers tend to analyse these datasets one by one and then ...

Introduction A substantial number of patients with major depressive disorder experience non-remission despite treatment with psychotherapy and several antidepressant drugs. This has increased the ...

1 NIHR CLAHRC for North West London, Chelsea and Westminster Hospital, London, UK 2 Department of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, UK Setting A wide range ...

Objectives To assess changes in quality of life and costs of patients undergoing primary total hip replacement using the Exeter prosthesis compared with a hypothetical ‘no surgery’ group. Design The ...

Objective To examine whether gender differences in primary care consultation rates (1) vary by age and deprivation status and (2) diminish when consultation for reproductive reasons or common ...

Objective People living with diabetes need and deserve high-quality, individualised care. However, providing such care remains a challenge in many countries, including Canada. Patients’ expertise, if ...

Background The urgency of the climate crisis requires attention from biomedical research, not least clinical trials which can involve significant greenhouse gas emissions. The Low Carbon Clinical ...

Objectives To provide a map of Anatomical Therapeutic Chemical (ATC) Classification System codes to individual Rx-Risk comorbidities and to validate the Rx-Risk Comorbidity Index. Design The 46 ...

Objective To evaluate the prevalence of wounds managed by the UK’s National Health Service (NHS) in 2017/2018 and associated health outcomes, resource use and costs. Design Retrospective cohort ...