We have generated transgenic mice carrying targeted deletions of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) gene. These animals offer the unique opportunity to gain insights into ...

The function of p53 as a tumor suppressor is mainly due to its activity as a transcription factor, activating many genes in response to genotoxic stress. This activity may be the basis for its ability ...

Next generation genomics technology is playing a significant role in improving the outcomes of genomic tools used in livestock farming, cultivation of crops, selection of quality seeds with improved ...

Researchers developed STRIPE, a targeted long-read RNA sequencing tool that identifies disease-causing variants missed by ...

Using single-nucleus RNA sequencing, the authors map transcriptional changes in the rat ventral tegmental area following chronic inflammatory pain and acute morphine exposure. Notably, their ...