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在方法学创新方面，孙博士率先将两亲性共聚高分子引入冷冻电镜的膜蛋白研究中，并依托该前沿技术成功解析了替代性复合物三的亚基空间排布与电子传递网络。此外，他利用重组抗体技术成功从脑组织中纯化出关键的神经受体（γ-氨基丁酸受体），并通过冷冻电镜系统阐明了其复杂的组装模式与药理学机制。相关核心成果已在 Nature、PNAS、J. Am. Chem. Soc.、Biochemistry ...