随着诱导接近机制不断拓展至更广泛的靶点类型和疾病领域，其分子设计复杂性与体内行为不确定性也显著提升。从分子胶和双功能降解剂，到细胞外或组织特异性降解策略，这类创新分子在跨膜渗透、分布、代谢及暴露-药效关系等方面均对研发体系提出了更高要求。如何在早期阶 ...

Japanese Prime Minister Sanae Takaichi has recently led Japan's Liberal Democratic Party to secure over two-thirds of the seats in the House of Representatives, achieving "one-party dominance" in ...