49ers host Matthew Stafford and the Rams in a key NFC West clash

San Francisco 49ers running back Christian McCaffrey (23) stiff-arms New York Giants cornerback Andru Phillips (22) during ...
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49ers' Christian McCaffrey: CBS Sports makes bold prediction for star RB

According to FanDuel Sportsbook, Indianapolis Colts running back Jonathan Taylor is the clear favorite (-135) to win NFL Offensive Player of the Year honors this season.