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一类与癌症相关的 POT1 突变可导致端粒主动延长。

染色体末端受到称为端粒的特殊结构的保护，端粒对于维持染色体稳定性和限制细胞生长至关重要。端粒上存在一种名为POT1的蛋白质，它在调节这些保护性末端的长度方面发挥着独特的作用。本文系统地测试了POT1的多种突变，以了解这些变化如何影响端粒的维持。
cirm.ca.gov

Continuous multiplexed phage genome editing using recombitrons.

Chloe B Fishman, Kate D Crawford, Santi Bhattarai-Kline, Darshini Poola, Karen Zhang, Alejandro Gonzalez-Delgado, Matias Rojas-Montero, Seth L Shipman Bacteriophage genome editing can enhance the ...
cirm.ca.gov

Conference – 2026 SPARK Annual Meeting

The objective of this request for applications (RFA) is to solicit a highly qualified applicant to develop and manage the 2017 annual meeting in support of the CIRM SPARK program. The SPARK program ...
cirm.ca.gov

Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty ...

Ayush D Midha, Yuyin Zhou, Bruno B Queliconi, Alec M Barrios, Augustinus G Haribowo, Brandon T L Chew, Cyril O Y Fong, Joseph E Blecha, Henry VanBrocklin, Youngho Seo, Isha H Jain Oxygen deprivation ...