Sunday in San Francisco, the 49ers (6-3) host the Los Angeles Rams (6-2) with first place on the line in the NFC West. Los Angeles blew out the Saints last week and as a result enters the game riding a three-game winning streak.

Two sets of division leaders clash to headline the NFL Week 10 schedule. On Sunday, the AFC East-leading New England Patriots, led by quarterback Drake Maye, battle the NFC South-leading Tampa Bay Buccaneers and quarterback Baker Mayfield.

The San Francisco 49ers got back to winning ways on Sunday, and it was thanks in large part to another strong performance from star running back Christian McCaffrey. The Niners were on the road at MetLife Stadium for Week 9. They took down the New York Giants, 34-24, to improve to 6-3 on the season.

SANTA CLARA, Calif. (AP) — The San Francisco 49ers have been aggressive at the trade deadline in past seasons, trading valuable draft picks for upgrades they believed could increase their chances of winning a Super Bowl.

San Francisco 49ers QB Mac Jones got effective protection to beat the Giants, but credit some of that success to Kyle Shanahan's plan for how to keep New York's vaunted pass rush from being a factor.

The New York Giants and San Francisco 49ers face off in Week 9 of the NFL regular season today. Here's where to watch and start time.

The 49ers’ lone move was sending a sixth-round pick to New England on Oct. 28 for end/tackle Keion White, who was a second-round pick in 2024 but not considered a fit with the defensive scheme brought in by coach Mike Vrabel. The 49ers also got back a seventh-round pick in the deal.

One NFL head coach has already been fired in 2025, as the Tennessee Titans parted ways with head coach Brian Callahan earlier this season. But more firings could be on the way on Sunday. Week 9 of the 2025 regular season is in full swing.