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What Is Sepsis? Sepsis is the body’s life-threatening response to infection. Instead of fighting off the infection in one area, the body’s immune system goes into overdrive and causes widespread inflammation. That inflammation can damage tissues and organs, leading to shock, organ failure, and death if untreated. The Classic Signs of Sepsis While sepsis can present differently depending on the patient and the infection source, pay attention to these subtle indicators in your assessment: Respirat