Is this the most powerful antidepressant combination? If a person has taken multiple antidepressant medications—at the highest therapeutic doses—for a prolonged period, such as six months or more, and they continue to experience depressive symptoms, then monotherapy, or using a single medication, may no longer be considered effective. That’s when dual antidepressant therapy is considered—particularly for patients whose symptoms remain resistant to single-drug treatment. One of the most talked-ab