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Helium Dilution Method Explained | Lung Volume Measurement in Respiratory Physiology

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Helium Dilution Method Explained | Lung Volume Measurement in Respiratory Physiology

In this medical lecture, we dive into the Helium Dilution Method, a key technique used to measure Functional Residual Capacity (FRC) and assess lung volumes in clinical and diagnostic settings. Learn how this method works, its advantages and limitations, and how it's applied in respiratory physiology and pulmonary function tests (PFTs). 📘 ...

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Dilution | Definition, Equation & Factors

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$13.5-2. Separation of Helium from Natural Gas. A typical composition of a natural gas (S1) is 0.5% He (A), 17.0% N2 (B), 76.5% CH4 (C), and 6.0% higher hydrocarbons (D). The membrane proposed to separate helium has a thickness of 2.54 × 10$^{-3}$ cm, and the permeabilities are $PA$ = 60 × 10$^{-10}$ cm$^3$ (STP) cm/(s cm$^2$ cm Hg), $PB$ = 3.0 × 10$^{-10}$, and $PC$ = 1.5 × 10$^{-10}$. It is assumed that the higher hydrocarbons are essentially nonpermeable ($PD$ ? 0). The feed flow rate is 2.0 ×$

13.5-2. Separation of Helium from Natural Gas. A typical composition of a natural gas (S1) is 0.5% He (A), 17.0% N2 (B), 76.5% CH4 (C), and 6.0% higher hydrocarbons (D). The membrane proposed to separate helium has a thickness of 2.54 × 10$^{-3}$ cm, and the permeabilities are $PA$ = 60 × 10$^{-10}$ cm$^3$ (STP) cm/(s cm$^2$ cm Hg), $PB$ = 3.0 × 10$^{-10}$, and $PC$ = 1.5 × 10$^{-10}$. It is assumed that the higher hydrocarbons are essentially nonpermeable ($PD$ ? 0). The feed flow rate is 2.0 ×

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Helium Dilution Technique Results

Static lung volumes measured by the gold standard body plethysmography. Through the utilisation of Boyle’s law in a sealed chamber we can non invasively and accurately calculate lung volumes and airways resistance. This has an advantage over other methods such as helium dilution which can underestimate volumes when airflow is obstructed. This is normally the test patients find most tricky so a very clear explanation and good coaching is needed! 🫁 👩🏼‍⚕️ #respiratory #respiratoryphysiologist #h

Static lung volumes measured by the gold standard body plethysmography. Through the utilisation of Boyle’s law in a sealed chamber we can non invasively and accurately calculate lung volumes and airways resistance. This has an advantage over other methods such as helium dilution which can underestimate volumes when airflow is obstructed. This is normally the test patients find most tricky so a very clear explanation and good coaching is needed! 🫁 👩🏼‍⚕️ #respiratory #respiratoryphysiologist #h

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